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Takotsubo Cardiomyopathy: Broken-Heart Syndrome

We've all probably heard the story of a couple, married many decades, one dies and within days the other dies - death by heartbreak. I wrote about heartbreak and the phenomenon of it causing quite literal physical pain within the body, so that Ibuprofen can help relieve grief. What is a rather new concept to me though is Takotsubo Cardiomyopathy, which is actual electrocardiogram abnormalities and abnormalities in the left ventricle as a result of heartbreak.

This diagnosis is almost exclusive to women, with 90 percent happening to women who are beyond menopause. Years of gender-based research has taught us that when it comes to heart health, sex differences matter. One striking example is the temporary heart condition known as takotsubo cardiomyopathy, also known as broken-heart syndrome, first described in 1990 in Japan. More than 90 percent of reported cases are in women ages 58 to 75. Research suggests that up to 5 percent of women suspected of having a heart attack actually have this disorder. Most people recover with no long-term heart damage.

Takotsubo cardiomyopathy is a weakening of the left ventricle, the heart's main pumping chamber, usually as the result of severe emotional or physical stress, such as a sudden illness, the loss of a loved one, a serious accident, or a natural disaster such as an earthquake. The main symptoms are chest pain and shortness of breath after severe stress (emotional or physical), but as mentioned, abnormalities that mimic a heart attack can be seen on an electrocardiogram. This is acute systolic heart failure. There is no evidence of coronary artery obstruction, but there is movement abnormalities in the left ventricle and ballooning of the left ventricle. There may also be rales in the lungs, a S3 gallop in the heart, venous distention in the jugulars, an elevated heart rate, low blood pressure, narrow pulse pressure, and a systolic ejection murmur. Elevation in cardiac biomarkers can also be seen, such as with the troponin, creatine kinase-myocardial band, and B-type natriuretic peptide. Typically these individuals are fully recovered within a month's time.

Not just hysteria anymore. Serious illnesses, surgery, severe pain, a sudden drop in blood pressure, an asthma attack - all potential scenarios that may instigate broken-heart syndrome. Domestic violence as well, an unexpected loss, a fierce argument, significant financial loss, and even receiving devastating news are other causes. Yes, even public speaking, a surprise birthday part, or an intense fear.

This diagnosis is often made when an individual with suspected acute myocardial infarction is found at cardiac catheterization to have no coronary blockage. Treatment is usually provided inpatient via cardiology and is typically supportive until function spontaneously returns, but can last 21 to 30 days. Diuretics and vasodilators are often utilized for pulmonary congestions, and ACE inhibitors, angiotensin II receptor blockers or beta-blockers are used to reduce workload and to control blood pressure.

And now you know.


Prasad. A., et al. (2008). American Heart Journal, 155(3), 408-417.

66 views2 comments


Crazy but now you have a case study to support. i never would’ve known a heart break can cause the physical or objective manifestation of a heart attack until it happened to me. .

Dr. Penny Lane
Dr. Penny Lane
Apr 05, 2023
Replying to

This is so heart-breaking for me. I wish I could fix it for ya.

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